Characterization of 2-((4-(Chloromethyl) benzoyl) oxy)benzoate Acid for Analgesic Tablet Dosage Form Formulation

Hadinugroho, Wuryanto, Tjahjono, Yudy, Foe, Kuncoro, Esar, . Senny Yesery, Caroline, Caroline and Jessica, Maria Anabella (2024) Characterization of 2-((4-(Chloromethyl) benzoyl) oxy)benzoate Acid for Analgesic Tablet Dosage Form Formulation. Current Research in Pharmacology and Drug Discovery, 7 (100200). pp. 1-10. ISSN 2590-2571

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Abstract

The 2-((4-(chloromethyl)benzoyl)oxy)benzoic acid (4CH2Cl) is a potential analgesic compound derived from salicylic acid and 4-chloromethyl benzoyl chloride. Characterization required 4CH2Cl for the formulation of tablet dosage forms. This study aims investigate the effect of SSG, PVP-K30, and the combination of SSG*PVP K- 30 on the formulation of 4CH2Cl tablets. Additionally, this study aimed to obtain the optimum 4CH2Cl tablet composition. The experiment followed the two-factor simplex lattice design and direct compression method. The analgesic activity of 4CH2Cl in the optimal tablet was investigated using the hot-plate methods. The ANOVA of

Item Type:	Article
Uncontrolled Keywords:	4CH2Cl Tablet Formulation Analgesic Simplex lattice design
Subjects:	Pharmacy
Divisions:	Journal Publication
Depositing User:	F.X. Hadi
Date Deposited:	18 Oct 2024 06:23
Last Modified:	27 Feb 2025 04:42
URI:	https://repositori.ukwms.ac.id/id/eprint/41054

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