Novita, Bernadette Dian (2018) Metformin Induced Autophagy In Diabetes Mellitus – Tuberculosis Co-Infection Patients: A Case Study. Indian Journal of Tuberculosis, 14 (262). pp. 1-6. ISSN 0019-5707
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Abstract
Metformin (MET) is a potential combination drug to elevate anti-TB efficacy. However, the clinical effect, especially smear reversion, during metformin applied with anti-tuberculosis and insulin in patients with type 2 DM newly TB co-infection were remain unknown. An observational clinical study was done in DM newly TB co-infection outpatients at Surabaya Paru Hospital. This study evaluated MET therapy, at least 2 months, accompanying with insulin and anti-TB regimens and compared to comparison group. The smear, microtubule-associated Protein1 Light Chain 3B (MAP1LC3B) level, as the presentation of autophagy, Superoxide Dismutase (SOD) level, Interferon (IFN) -γ and Interleukin (IL) -10 levels were evaluated twice. From 42 participants in this study, 22 participants of observation group that received additional MET therapy, 100% had sputum smear reversion after 2-months intensive phase of anti-TB therapy. Whereas 25% of 20 participants of comparison group did not undergo reversion inserts sputum smear. As conclusion, MET has the potential of being an additive combination therapy to enhance the bactericidal effect of anti-TB on DM-TB coinfection patients. Metformin enhances the effects of anti-TB and insulin therapy in increasing the smear reversion by increasing autophagy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | type 2 diabetes mellitus-tuberculosis co-infection patients; metformin; AFB smear reversion; and autophagy |
| Subjects: | Medicine Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Journal Publication |
| Depositing User: | Dr Bernadette Dian Novita Dewi |
| Date Deposited: | 23 Apr 2018 05:59 |
| Last Modified: | 22 Feb 2019 01:12 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/14524 |
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