Lestari, Kusuma S., Sincihu, Yudhiakuari, Latif, Mohd Talib, Elias, Saliza Mohd, Soemarno, Troef and Keman, Soedjajadi (2025) No Prominent SOD and CAT Lung Expression of Rats Due to Exposure to Low-Density Polyethylene in The Air. Journal of Medicinal and Chemical Sciences, 8 (1). pp. 18-30. ISSN 26514702
![[thumbnail of No Prominent SOD and CAT Lung Expression of Rats Due to Exposure to Low-Density Polyethylene in The Air]](https://repositori.ukwms.ac.id/style/images/fileicons/text.png) |
Text (No Prominent SOD and CAT Lung Expression of Rats Due to Exposure to Low-Density Polyethylene in The Air)
2-No_prominent_SOD_and_CAT_lung_v.pdf Download (991kB) |
Abstract
Microplastics are plastic particles less than 5 mm in diameter that contaminate the environment. Humans and animals can inhale microplastics measuring 2 μm to 1 mm in the air. There has been limited research on inhalation exposure to low-density polyethylene (LDPE) microplastics. This study aimed to investigate the Reactive Oxygen Species (ROS) in the Wistar strain of Rattus norvegicus due to exposure to LDPE in the air. This study is an experimental study using a post-test control group design on the Wistar strain of Rattus norvegicus. Five experimental groups (X1 to X5) were each given LDPE microplastic particles with concentrations of 1 mg/L, 1.25 mg/L,2.5 mg/L, 3.75 mg/L, and 5 mg/L for 28 days. This result showed the SOD and CAT enzymes were not present or active. There was no difference among groups of both SOD and CAT enzymes. The microplastic particle in the blood (/mL) was identified in each intervention groups which was 6.80 ± 2.58 (X1), 17.67 ± 9.02 (X2), 35.83 ± 12.22 (X3), 41.17 ± 14.72 (X4), and 57.50 ± 6.47 (X5) while in control group was 1.80 ± 1.30 with fragments being the most dominant form of microplastics. It can be concluded that ROS was not seen due to the dose, chamber condition, and exposure technique should be intratracheal. The greater the dose of LDPE exposure, the greater the average microplastics in the blood of the Wistar strain of Rattus norvegicus in both the control and intervention groups.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Airborne microplastics Low-density polyethylene Reactive Oxygen Species Microplastics in rat blood Air pollution. |
| Subjects: | Medicine |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 19 Dec 2025 08:32 |
| Last Modified: | 19 Dec 2025 08:32 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/45064 |
Actions (login required)
 |
View Item |