Foe, Kuncoro, Tjahjono, Yudy, Ervina, Martha and Karel, Philipus (2025) 2‑((3‑(chloromethyl) benzoyl) oxy) benzoic acid suppresses NF‑κB expression in the kidneys and lungs of LPS‑Induced BALB/C mice. journal of advanced pharmaceutical technology and research, 16 (3). pp. 163-168.
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Abstract
Sepsis, a life‑threatening systemic inflammatory condition, is a leading cause of mortality worldwide. Its pathophysiology involves the activation of nuclear factor kappa beta (NF‑κB), which promotes the release of proinflammatory cytokines. Acetylsalicylic acid (ASA), a widely used nonsteroidal anti‑inflammatory drug, inhibits NF‑κB but poses risks of peptic ulcer disease and nephrotoxicity. This study evaluates the efficacy of 2‑((3‑(chloromethyl)benzoyl)oxy)benzoic acid (3‑CH2 Cl), a novel salicylate derivative, in reducing NF‑κB expression in the kidneys and lungs of lipopolysaccharide (LPS)‑induced septic BALB/C mice. Mice were divided into four groups: untreated, LPS only, LPS + ASA (60 mg/kg BW), and LPS + 3‑CH2 Cl (60 mg/kg BW). NF‑κB expression was assessed via immunohistochemistry. LPS significantly increased NF‑κB expression in both renal and pulmonary tissues compared to controls (P < 0.0001). While ASA treatment reduced NF‑κB levels (P < 0.0001), 3‑CH2 Cl demonstrated superior suppression in the renal cortex, renal medulla, and alveolar regions (P < 0.05). In addition, 3‑CH2 Cl alleviated hypothermia in septic mice, comparable to ASA. Given its enhanced anti‑inflammatory efficacy and reduced gastrointestinal risk, 3‑CH2 Cl presents a promising alternative to ASA for sepsis‑related inflammation management. Further studies are warranted to explore its clinical applications. Key words: 3‑CH2 Cl, acetylsalicylic acid, immunohistochemistry, inflammation, lipopolysaccharide, NF‑κB
| Item Type: | Article |
|---|---|
| Subjects: | Pharmacy > Pharmacist Professional |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Brilliant Dwi Putra |
| Date Deposited: | 11 Nov 2025 10:05 |
| Last Modified: | 11 Nov 2025 10:05 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44665 |
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