Tjahjono, Yudy, Foe, Kuncoro and Wilianto, Yufita Ratnasari (2024) HPinulin-MCTdietaryfiberimproveslipidmetabolismandprevents non-alcoholicsteatohepatitisinobesemice. journal of functional foods, 120 (-). pp. 1-9. ISSN 1756-4646/
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Abstract
Introduction:Regular intakeofdietaryfiber (DF) cancounteract thenegative impactsofobesityonphysical healthandchronicdiseaserisk.DFmitigatesobesitybypromotingfullness,reducingcalories,slowingnutrient absorption, stabilizingglucose,preventingfatstorage,andinfluencinggutmicrobiota.High-performance(HP) inulin, ahighlyfermentablewater-solubleDF, showspromise,but itspalatabilityis limitedinpowder form. CombiningHPinulinwithbeneficialtriglycerideslikeMediumChainTriglycerides(MCT)couldovercomethis issue. Aimofstudy:ThisstudyinvestigatestheeffectsofHPinulin-MCTonlipidmetabolismandimmunemodulationin high-fathigh-sucrose(HFHS)diet-inducedobesemice. Methods:Obesemicewereorallyadministeredwith20%(w/v)HP inulin-MCTad-libitumfor30days.We measuredtheirperipheralbloodlipidprofile, includingLDL,HDL,andtriglycerides.Additionally, theathero geniccoefficient,aparameterforassessingcardiovasculardiseaserisk,wasdeterminedbycalculatingtheratioof non-HDL-CtoHDL-C.FlowcytometrywasusedtoidentifysplenicregulatoryCD4+andCD8+Tcells(Tregs). TheNon-AlcoholicSteatohepatitisScorewasassessedthroughhistologicalexamination. Results:Significant reducedbodymass index, improvedlipidprofiles,andreducedcardiovasculardiseaserisk wereobservedintheobesemicetreatedwithHPinulin-MCT.Moreover,HPinulin-MCTappearedtoameliorate non-alcoholicsteatohepatitis,aliverconditionassociatedwithobesity.Thesehealthimprovementswerelinked to immune systemmodulation, associatedwithan increaseofCD4+T-regulatorycellsafterHP inulin-MCT supplementation. Conclusion:HP inulin-MCTisapromisingandpalatabledietary interventiontocombat obesity-relatednon communicablediseases,offeringthepotential forbetteroverallhealthoutcomes.
| Item Type: | Article |
|---|---|
| Subjects: | Pharmacy > Pharmacist Professional |
| Divisions: | Faculty of Pharmacy |
| Depositing User: | Brilliant Dwi Putra |
| Date Deposited: | 11 Nov 2025 10:04 |
| Last Modified: | 11 Nov 2025 10:04 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44662 |
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