Handoyo, Henry Ricardo, Fitri, L.E, Hidayat, Mohamad, Sardjono, Teguh Wahju and Soeharto, Gebby Pradana (2023) Combined Extract (Curcuma Longa-Glycyrrhiza Glabra) Alleviates The Anflammations of Achilles Tendinopathy in Wistar Rats. European Review for Medical and Pharmacological Sciences, 27 (20). pp. 9668-9679. ISSN pISSN: 11283602 eISSN: 22840729
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Abstract
OBJECTIVE: Achilles tendinopathy is a frequent pathological condition in adults with overused ankles, causing microtrau ma, inducing tenocyte apoptosis and inflammatory response. Common treatment involves oral prescription or injection of anti-inflamma tory agents, surgery, or shock-wave therapy. However, prolonged administration is not advis able due to adverse effects. Therefore, a novel and safe regimen is needed. Curcuma longa and Glycyrrhiza glabra extracts are known for their anti-inflammatory effects owing to their active compounds (curcumin and glycyrrhizin, respec tively). This study aimed to determine the effect of combined extracts of Curcuma longa and Gly cyrrhiza glabra on tendon healing in an animal model of Achilles tendinopathy (Wistar rats). MATERIALS AND METHODS: This study took place from February to May 2022 and compared the regimens administered to 32 animal mod els of Wistar rats with 4 healthy rats as a control group to determine the most effective therapeutic regimen: immobilization, immobilization with ibu-profen, or immobilization with the combined extract. The outcomes were measured to find which intervention provided the lowest inflammatory markers [High Mobility Group Box-1 (HMGB-1), Tumor Necrosis Factor- α (TNF- α), Chemokin mo tif ligand 12 (CXCL-12)], and improved tissue morphology represented by the BONAR score, decreased cross-sectional area (CSA), and in creased Macrophage 2 (M2) differentiation. RESULTS: After Achilles tendinopathy was induced, total immobilization (I1) was proven to be the most effective with the lowest CSA, whereas immobilization+175 mg/kg Curcuma longa+110 mg/kg Glycyrrhiza glabra extract (I5) was the most effective with the lowest HMGB-19668 1,2 , L.E. FITRI 3, M. HIDAYAT 4 , T.W. SARDJONO levels and the lowest CXCL-12 levels. Immobilization+131 mg/kg Curcuma longa+82.5 mg/kg Glycyrrhiza glabra extract (I6) was the most ef fective with the lowest Bonar score, while immobilization+87.5 mg/kg Curcuma longa+55 mg/kg Glycyrrhiza glabra extract (I7) was proven to be the most effective with the highest M2 coverage area and the lowest TNF-α levels. CONCLUSIONS: We found that combined ex tract therapy was the most effective intervention for treating Achilles tendinopathy due to its abil ity to provide the lowest inflammatory markers.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Bonar score, Chemokin motif ligand 12, Curcuma longa, Glycyrrhiza glabra, High Mobility Group Box-1, Macrophage 2, Tumor Necrosis Factor-α. |
| Subjects: | Medicine |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 24 Oct 2025 09:09 |
| Last Modified: | 24 Oct 2025 09:09 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44620 |
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