Soetaredjo, Felycia Edi, Ismadji, Suryadi, Santoso, Shella Permatasari, Putro, Jindrayani Nyoo, Foe, Kuncoro and Waworuntu, Gladdy Lysias (2024) pH-Sensitive CNC-Chitosan Hydrogel for Drug Delivery. Lett. Appl. NanoBioSci, 13 (4). pp. 1-11. ISSN 2284-6808
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Abstract
In contemporary society, inflammatory bowel disease (IBD) is prevalent and acknowledged. In treating inflammatory bowel disease (IBD), pH-sensitive drug delivery systems are commonly utilized. Nonetheless, their efficacy tends to be reduced as a result of modifications in the pH levels within the intestines. This study aims to develop a medication delivery system responsive to changes in pH to deliver 5-aminosalicylic acid specifically to the colon. CNC-chitosan hydrogel was produced by implementing the cross-linking technique, employing glutaraldehyde as the cross-linking agent. The hydrogel was subjected to characterization using scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling capacity analysis, and Fourier-transform infrared spectroscopy (FTIR). The release kinetics of 5-aminosalicylic acid from cellulose nanocrystals (CNC) and CNC-chitosan composites showed superior performance at pH 7.4 compared to pH 2.4. The release profile of 5aminosalicylic acid from CNC-chitosan hydrogel can be accurately represented by the KorsemeyarPeppas equation. CNC and CNC-chitosan were compatible with osteoblast cells, indicating their lack of toxicity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sustained-release; hydrogel; inflammatory bowel disease. |
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 01 Oct 2025 07:40 |
| Last Modified: | 01 Oct 2025 07:40 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44566 |
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