Tjahjono, Yudy, Caroline, Caroline, Nugraha, Jusak, Foe, Kuncoro, Karnati, Srikanth, Ergün, Süleyman, Jafet, Nico 
ORCID: https://orcid.org/0000-0001-5960-9732, Chrisantia, Oryza, Kusuma, I Made Andika Bara, Wijaya, Hendy, Hadinugroho, Wuryanto, Nugrahaningsih, Dwi Aris Agung, Kusindarta,, Dwi Liliek, Wilianto, Yufita Ratnasari, Esar, . Senny Yesery and Wihadmadyatamib, Hevi
(2023)
2-(3-(Chloromethyl) benzoyloxy)benzoic acid increases CD4 regulatory T-cell population and FoxP3 expression in lipopolysaccharide-induced mice.
The Indonesian Biomedical Journal, 15 (4).
pp. 339-346.
ISSN pISSN: 20853297, eISSN: 23559179
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Text (2-(3-(Chloromethyl) benzoyloxy)benzoic acid increases CD4 regulatory T-cell population and FoxP3 expression in lipopolysaccharide-induced mice.)
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Abstract
BACKGROUND: Lipopolysaccharide (LPS) has been reported to increase CD4 regulatory T-cell (CD4 ++ Treg) populations. Acetylsalicylic acid (ASA) has been reported to have immunomodulatory activity, but it may induce chronic gastric ulceration. Another salicylic acid-bearing compound, 2-(3-(chloromethyl) benzoyloxy)benzoic acid (3-CH2Cl), has been reported to have less gastric mucosal damage. However, the effect of 3-CH2 Cl on CD4 Tregs in LPS-induced mice is still unknown. Therefore, the present study was conducted to investigate the immunomodulatory effect of 3-CH+Cl on CD4 + 2-(3-(chloromethyl)benzoyloxy)benzoic Acid Increases CD4 T-cell and CD4 Treg populations as well as FoxP3 expression in LPS-induced mice.++ Regulatory T-Cell Population and FoxP3 Expression in Lipopolysaccharide-induced Mice Yudy Tjahjono Abstract METHODS: Synthesis of 3-CH 1,2,#, Caroline Cl was performed by mixing salicylic acid and chloromethylbenzoylchloride with the catalyzation of pyridine, acetone and heat. The 3-CH2Cltablets were prepared using direct compression method. After intraperitoneal injection of 1 mg/kg BW LPS to mice, 60 mg/kg BW ASA or 60 mg/kg BW 3-CH21,#, Jusak Nugraha 22Cl was given 3, Kuncoro Foe orally for 3 days. The splenocyte was obtained through splenectomy and collagenase digestion. The population of CD4 + T-cells and CD4 Tregs, as well as the splenic FoxP3 expression were determined using flow cytometry technique. RESULTS: CD4 ++ T-cell populations in mice treated with LPS and 3-CH Cl or ASA were lower than those treated with LPS merely. Meanwhile, CD421, Srikanth Karnati,Süleyman Ergün 3 624, Nico Jafet 1, Oryza Chrisantia 1, I Made Andika Bara Kusuma, Wuryanto Hadinugroho 11, Dwi Aris Agung Nugrahaningsih 5 Treg populations and FoxP3 expression levels in mice treated with LPS and 3-CH + ASA were higher than those treated with LPS merely. CONCLUSION: Since 3-CH T-cell population and increase CD4 2 Cl could decrease CD4 Treg population mediated by the increase of FoxP3 expression in LPSinduced inflammation, it may act as a potential therapeutic drug to reduce inflammatory conditions. +
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 2-(3-(chloromethyl)benzoyloxy)benzoic acid, acetylsalicylic acid, CD4, T-regulatory cells, FoxP3, LPS |
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 01 Oct 2025 07:31 |
| Last Modified: | 01 Oct 2025 07:31 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44565 |
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