Caroline, Caroline, Nathania, Nathania, Foe, Kuncoro, Esar, . Senny Yesery and Jessica, Maria Anabella (2019) Characterization of pharmacokinetics of 2-(3-(chloromethyl)benzoyloxy)benzoic acid in rats by using HPLC-DAD method. International Journal of Applied Pharmaceutics,, 11 (5). pp. 279-283. ISSN 0975-7058
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Abstract
Objective: A new compound of salicylic acid derivative, namely 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid (3CBB), was synthesized to find a compound exhibiting higher analgesic activity and smaller ulcer irritation than acetylsalicylic acid (ASA). Therefore, this study aimed to investigate the pharmacokinetics of this new compound in rats, following a single dose oral administration of 3CBB (45 mg/kg BW). Methods: Plasma samples of 9 healthy rats were collected before and up to 3 h after its oral administration, following an 18 h fasting period. Plasma concentrations of 3CBB were determined using a validated HPLC-DAD assay. Pharmacokinetic parameters were determined using the compartment model technique. All experiments were carried out in triplicate. Results: The pharmacokinetic parameters of 3CBB obtained were as follows: Tmax = 28.9±1.1 min, C max = 0.57±0.02 µg/ml, AUC total= 66.3±1.0 µg min/ml, K el = 0.018±0.002 min indicated that 3CBB was extensively distributed in the deep and very deep tissues. This confirmed the unique and special characteristics of a highly lipophilic compound like 3CBB (log P = 3.73). -1, and T 1/2el = 39.4±3.9 min. The long elimination half-life and low C max Conclusion: 3CBB demonstrated a slower onset of action and longer elimination time from the body compared to ASA. Thus this new compound is a potential candidate to be developed as a new drug.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 2-((3-(Chloromethyl)benzoyl)oxy)benzoic acid, Pharmacokinetics, Rat, HPLC-DAD |
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 01 Oct 2025 06:10 |
| Last Modified: | 01 Oct 2025 06:10 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44559 |
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