Meryana, Pauline, Sugianto, Paulus, Erwin, Ferdinand and Jaya, David Karunia (2024) Vitamin B Supplementation in Geriatric Patients: A Potential Strategy to Managing Hyperhomocysteinemia in Cerebrovascular Disease. Journal of Widya Medika, 10 (2). pp. 144-162. ISSN pISSN: 2338-0373, eISSN: 2623-2723
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Abstract
Homocysteine is an amino acid synthesized in the metabolic pathway between methionine and cysteine. Its levels tend to rise with age due to physiological, lifestyle, and utritional factors. Elevated homocysteine can induce oxidative stress, inflammation, and endothelial dysfunction, which are critical in the development of cerebrovascular diseases. These mechanisms involve increased free radicals, decreased antioxidant enzyme activity, and enhanced inflammatory responses. Specifically, elevated homocysteine heightens oxidative stress and inflammation by increasing pro-inflammatory cytokines and decreasing anti-inflammatory cytokines, leading to endothelial cell damage and apoptosis. Supplementation with vitamins B6, B9, and B12 has been shown to lower homocysteine levels and reduce the risk of ischemic stroke. However, there is currently no established guideline for the appropriate dosing of these vitamins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Homocysteine, Cerebrovascular, Stroke, Geriatric, Vitamin B |
| Subjects: | Medicine |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 26 Aug 2025 05:40 |
| Last Modified: | 26 Aug 2025 05:40 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44420 |
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