Putri, Patricia Dian, Rusyati, Luh Made Mas and Adiguna, Made Swastika (2020) Negative correlation between interleukin-2 (IL-2) serum with bacterial index in leprosy. Bali Dermatology and Venereology Journal (BDV), 3 (1). pp. 19-22. ISSN pISSN: 20891180 eISSN: 23022914
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Abstract
Background: Leprosy is strongly influenced by the host immunity response. One of the cytokines that play a role in cellular immunity is IL-2. IL-2 will stimulate macrophages to activate phagocytosis and form granulomas, and this occurs in the leprosy tuberculoid type. Aim of this study was to verify the IL-2 serum levels are negatively correlated or not with bacterial index in leprosy. Methods: This study was a cross-sectional observational analytic study involving 50 leprosy subjects (41 MB and 9 PB types). Study was conducted at Dermatolovenerology Polyclinic of Sanglah General Hospital from December 2019 to March 2020. Ridley’s scale was used to determine bacterial index (BI). IL-2 serum levels were measured by ELISA. Result: The mean of IL-2 serum in PB was 75.53±10.32 pg/mL 1 ORIGINAL ARTICLE Bali Dermatology and Venereology Journal (BDV) 2020, Volume 3, Number 1, 19-22 P-ISSN.2089-1180, E-ISSN.2302-2914 , Made Swastika Adiguna 1 and in MB was 37.59±17.13 pg/mL. Strong negative correlation (r= -0.67; p<0.001) between serum IL-2 levels with bacterial index (CI 95%= 25.96–49.93; p<0.001) was found. Every 1 pg/mL increase in IL-2 serum levels will be accompanied by a decrease in the bacterial index of 0.039 and vice versa. Determinant coefficient shows that 42.2% of the BI is affected by the IL-2 serum levels. Low IL-2 serum levels were the risk factor of high BI 2.8 times (PR= 2.8; CI 95%= 1.444–5.519; p<0.001). Conclusion: IL-2 serum levels were found to be higher in PB than MB. There was a negative correlation between IL-2 serum levels with bacterial index. Low IL-2 serum levels were the risk factor of a high bacterial index in leprosy patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Leprosy, IL-2 serum, bacterial index |
| Subjects: | Medicine |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 14 Aug 2025 06:15 |
| Last Modified: | 14 Aug 2025 06:15 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44395 |
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