Kurahashi, Yukiya, Furukawa, Koichi, Sutandhio, Silvia, Tjan, Lidya Handayani, Iwata, Sachiyo, Sano, Shigeru, Tohma, Yoshiki, Ohkita, Hiroyuki, Nakamura, Sachiko, Nakamura, Sachiko, Nishimura, Mitsuhiro, Arii, Jun, Kiriu, Tatsunori, Yamamoto, Masatsugu, Nagano, Tatsuya, Nishimura, Yoshihiro and Mori, Yasuko (2022) Cross-Neutralizing Activity Against Omicron Could Be Obtained in SARS-CoV-2 Convalescent Patients Who Received Two Doses of mRNA Vaccination. The Journal of Infectious Diseases, 226 (8). pp. 1391-1395. ISSN eISSN: 1537-6613, pISSN: 0022-1899
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Abstract
The severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) variant omicron is now under investigation. We evaluated cross-neutralizing activity against omicron in coronavirus disease 2019 (COVID-19) convalescent patients (n=23) who had received 2 doses of an mRNA vaccination (BNT162b2 or mRNA-1273). Intriguingly, after the second vaccination, the neutralizing antibody titers of subjects against SARS-CoV-2 variants, including omicron, all became seropositive, and significant fold-increases (21.1–52.0) were seen regardless of the disease severity. Our findings thus demonstrate that 2 doses of mRNA vaccination to SARSCoV- 2 convalescent patients can induce cross-neutralizing activity against omicron.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SARS-CoV-2; COVID-19; omicron; crossneutralizing antibody; convalescent. |
| Subjects: | Medicine |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 24 Jul 2025 03:30 |
| Last Modified: | 24 Jul 2025 03:30 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44205 |
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