Kurahashi, Yukiya, Sutandhio, Silvia, Furukawa, Koichi, Tjan, Lidya Handayani, Iwata, Sachiyo, Sano, Shigeru, Tohma, Yoshiki, Ohkita, Hiroyuki, Nakamura, Sachiko, Nishimura, Mitsuhiro, Arii, Jun, Kiriu, Tatsunori, Yamamoto, Masatsugu, Nagano, Tatsuya, Nishimura, Yoshihiro and Mori, Yasuko (2022) Cross-Neutralizing Breadth and Longevity Against SARS-CoV-2 Variants After Infections. Frontiers in Immunol, 13 (773652). pp. 1-10. ISSN 1664-3224
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Abstract
Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible for the Coronavirus Disease 2019 (COVID-19) pandemic. The emergence of variants of concern (VOCs) has become one of the most pressing issues in public health. To control VOCs, it is important to know which COVID-19 convalescent sera have cross-neutralizing activity against VOCs and how long the sera maintain this protective activity. Methods: Sera of patients infected with SARS-CoV-2 from March 2020 to January 2021 and admitted to Hyogo Prefectural Kakogawa Medical Center were selected. Blood was drawn from patients at 1-3, 3-6, and 6-8 months post onset. Then, a virus neutralization assay against SARS-CoV-2 variants (D614G mutation as conventional strain; B.1.1.7, P.1, and B.1.351 as VOCs) was performed using authentic viruses. Results: We assessed 97 sera from 42 patients. Sera from 28 patients showed neutralizing activity that was sustained for 3-8 months post onset. The neutralizing antibody titer against D614G significantly decreased in sera of 6-8 months post onset compared to those of 1-3 months post onset. However, the neutralizing antibody titers against the three VOCs were not significantly different among 1-3, 3-6, and 6-8 months post onset. Discussion: Our results indicate that neutralizing antibodies that recognize the common epitope for several variants may be maintained for a long time, while neutralizing antibodies having specific epitopes for a variant, produced in large quantities immediately after infection, may decrease quite rapidly.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SARS-CoV-2, COVID-19, variants, neutralization, breadth |
| Subjects: | Medicine |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 24 Jul 2025 01:32 |
| Last Modified: | 24 Jul 2025 01:32 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/44201 |
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