Hadisoewignyo, Lannie, Safitri, Dwi Qonita, Sinansari, Restry, Prasetyo, Jefri, Santoso, Kevin Owen, Damayanti, Salwa, Afotia, Dilla Sonia Wahyu and Soeliono, Ivonne (2025) Formulation, Optimization, and In Vitro Studies of Roasted Agung Banana var. Semeru Peel Effervescent Antidepressant Tablet. Journal of Pharmaceutical Innovation, 20 (4). p. 137. ISSN 1872-5120 e-ISSN: 1939-8042
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Abstract
Purpose To make effervescent tablet which being able to used for large doses of active ingredient, improve palatability, and simplify the manufacture of an effervescent tablet containing roasted banana peel extract (RBPE) via hot melt extrusion, and to optimise its formulation while assessing its antidepressant activity. Methods Effervescent granules were produced by hot melt extrusion and compressed directly into tablets. Optimisation employed a two-factor, two-level factorial design, with crospovidone (8–10% w/w) and effervescent base (50–55% w/w) as independent variables. The antidepressant activity of the optimised formulation was evaluated in mice using the forced-swim test (FST) and tail-suspension test (TST). Results A higher crospovidone concentration significantly shortened disintegration time (p<0.05). The proportion of effervescent base, and its interaction with crospovidone, significantly affected tablet hardness and friability (p<0.05). In both the FST and TST, the optimised RBPE tablet reduced immobility time to the same extent as fluoxetine and crude RBPE, indicating comparable antidepressant efficacy. Conclusions The optimised RBPE effervescent tablet disintegrated rapidly, met physical quality specifications, and exhibited significant antidepressant activity, supporting its potential as a convenient dosage form for RBPE
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Effervescent tablet · Roasted banana peel extract · Hot melt extrusion · Factorial design · Antidepressant activity |
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | Lannie Hadisoewignyo |
| Date Deposited: | 15 Jul 2025 10:28 |
| Last Modified: | 25 Jul 2025 09:47 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/43829 |
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