Redefining the hepatoprotective potential of Javanese turmeric (Curcuma xanthorrhiza) Kombucha towards the diethylnitrosamine-induced hepatotoxicity of mice

Subaidah, Elok, Dea, Eirene Charista, Saparianti, Ella, Putri, Rhytia Ayu Christianty, Sujuti, Hidayat, Srianta, Ignatius, Godelive, Laura and Tewfik, Ihab Redefining the hepatoprotective potential of Javanese turmeric (Curcuma xanthorrhiza) Kombucha towards the diethylnitrosamine-induced hepatotoxicity of mice. Nutrition & Food Science, 54 (3). p. 2024. ISSN 0034-6659

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Abstract

Purpose – This research intended the utilization of Javanese turmeric (0.4% w/v) as a kombucha substrate and analysis of its hepatoprotective activity, in comparison against nonfermented Javanese turmeric beverage (JTB) and black tea kombucha. Design/methodology/approach – Forty-two healthy male Balb/c mice (two- to three-week-old, 20–30 g) were divided into six groups with seven replicates each. The treatments were normal diet, normal diet þ Javanese turmeric kombucha (JTK), normal diet þ diethylnitrosamine (DEN), DEN þ JTB, DEN þ JTK, DEN þ black tea kombucha. Kombuchas and JTB were given at 0.3 mL/20 g BW/d. DEN was induced intraperitoneally at a dose of 100 mg/kg. Observed biomarkers were blood serum glutamate pyruvate transaminase (SGPT) and serum glutamate oxaloacetate transaminase (SGOT) activity, serum malonaldehyde (MDA), as well as liver histology. Data were analyzed using analysis of variance. Findings – Among DEN-induced groups, JTK significantly (p < 0.05) diminished the level of blood SGPT, SGOT and serum MDA. JTK also had lower blood SGPT (8.604 6 2.195 U/L) and serum MDA levels

Item Type:	Article
Subjects:	Agriculture and Food Technology
Depositing User:	Christine Limbara
Date Deposited:	08 May 2025 09:21
Last Modified:	08 May 2025 09:21
URI:	https://repositori.ukwms.ac.id/id/eprint/43146

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