pH‐responsive drug carriers MIL‐125(Ti)‐NH2 and MIL‐125(Ti) for delivering colorectal cancer therapeutics 5‐fuorouracil

Putro, Jindrayani Nyoo, Soetaredjo, Felycia Edi, Yuliana, Maria, Santoso, Shella Permatasari, Sugianto, jenyfer, Kelvin, Wijaya, Christian Julius, Wenten, I Gede and Ismadji, Suryadi (2025) pH‐responsive drug carriers MIL‐125(Ti)‐NH2 and MIL‐125(Ti) for delivering colorectal cancer therapeutics 5‐fuorouracil. Journal of Porous Materials. ISSN 1380-2224

Text (Artikel) 8. pH-responsive drug carriers MIL-125(Ti)-NH2 and MIL-125(Ti) (1).pdf Download (2MB)

Abstract

MIL-125(Ti) and its many modifications have demonstrated excellent biocompatibility, indicating significant potential as a drug carrier. This study examined the delivery potential of 5-fluorouracil using MIL-125(Ti) or MIL-125(Ti)-NH2. The synthesis of the two MOFs was conducted solvothermally at a temperature of 175 °C. This solvothermal approach yielded MOFs with distinct and clear diffraction peaks, indicating the high crystallinity of both resulting MOFs. Based on the nitro gen adsorption analysis, the surface areas for both MOFs were 712 m2/g for MIL-125(Ti) and 892 m2/g for MIL-125(Ti) NH2. Both MOFs synthesized in this study possess micropore and small mesopore structures. In the 5-fluorouracil loading experiment, MIL-125(Ti) exhibited a maximum loading capacity of 118.7 mg/g (47.48%), whereas MIL-125(Ti)-NH2 had 138.4 mg/g (55.36%). The drug release kinetics follow Higuchi and Ritger-Peppas methods with a maximum release of 5-fluorouracil more than 92% for MIL-125(Ti)-NH2 achieved within 48 h and 88% for MIL-125(Ti). The optimum pH for 5-fluorouracil release is 5.5. The cytotoxicity of both MOFs to osteoblast cells indicates their non-toxic characteristics.

Item Type:	Article
Uncontrolled Keywords:	Drug loading · Drug release · Ti-based MOF · Micropore · Mesopore
Subjects:	Engineering
Depositing User:	Sheilla Sheilla
Date Deposited:	06 May 2025 07:36
Last Modified:	06 May 2025 07:36
URI:	https://repositori.ukwms.ac.id/id/eprint/43106

Actions (login required)

View Item