Polysaccharide Polyelectrolyte Complex for Hydrophobic Drug Loading and Controlled Release

Putro, Jindrayani Nyoo, Tulus, Hana Fransisca, Wijaya, Christian Julius, Mangindaan, Dave, Irawaty, Wenny, Gunarto, Chintya, Puspitasari, Nathania, Angkawijaya, Artik Elisa, Rahmawati, Astrid, Shimomura, Osamu and Ismadji, Suryadi (2024) Polysaccharide Polyelectrolyte Complex for Hydrophobic Drug Loading and Controlled Release. Emergent Materials. ISSN 25225731, 2522574X

Text (Artikel) 5. Polysaccharide polyelectrolyte.pdf Download (3MB)

Abstract

The use of natural-based polymer is currently limited due to its hydrophilic properties. This study investigates durian seed gum for applying a drug delivery system with the combination of chitosan as complex coacervate. The successful syn- thesis of durian seed gum–chitosan polyelectrolyte complex (PEC) occurred through the electrostatic interaction between gum and chitosan, confirmed by the FTIR spectra and H1 NMR of PEC. The analysis of Zeta Potential also showed the behavior of pH-responsive material, 3.42 mV in pH 2.0 and −28.8 in pH 7.4. Other characterizations, such as SEM, TGA, DSC, and particle size analysis, were conducted to understand PEC’s characteristics further. The entrapment efficiency of dexamethasone using PEC was greater than 90%, with a high loading content of around 4 mg/gram PEC. The drug release profile from PEC follows the mechanism of polymer swelling and non-Fickian diffusion. The combination of durian seed gum and chitosan as a coacervate greatly enhances the controlled release of hydrophobic drugs. This suggests that durian seed gum–chitosan PEC has promising potential for use in pharmacokinetic research.

Item Type:	Article
Uncontrolled Keywords:	Polyelectrolyte complex · Durian seed gum · Chitosan · pH-responsive · Dexamethasone release
Subjects:	Engineering
Depositing User:	Christine Limbara
Date Deposited:	06 May 2025 06:49
Last Modified:	06 May 2025 06:49
URI:	https://repositori.ukwms.ac.id/id/eprint/43101

Actions (login required)

View Item