Hadinugroho, Wuryanto, Winarko, Stephanie Florencia, Sinta, Echa Imanuela, Esar, Senny Yesery and Prasetyo, Jefri (2025) Utilization of poly-2-hydroxypropane-1,2,3-tricarboxylic carubin as a glidant in lactose granules. Hybrid Advances, 11. pp. 1-9. ISSN 2773-207X
Preview |
Text (Artikel jurnal)
III.A.1.b.1_7.pdf Download (2MB) | Preview |
Abstract
Poly-2-hydroxypropane-1,2,3-tricarboxylic carubin (P-2HTCb) has characteristics as a glidant similar to talc and magnesium stearate (MgSt), such as irregular shape, wavy surface, difficulty dissolving in water, and hydrophobicity. The experiment’s purpose is to determine the effect and potential of P-2HTCb as a glidant in tablet dosage form with lactose granules (LG) as a filler model. The application of P-2HTCb as a glidant represents a novelty. P-2HTCb was used in each of mixture mass with contents of 0.5 %, 1 %, 2 %, and 4 %. Each mixture mass was tested for flow time, angle of repose, and Tap-Bulk, then tableted with a weight of 700 mg. The tablets were tested for hardness, friability, and disintegration time. Evaluation of the mixture mass with concentrations of 0.5%, 1%, 2%, and 4% for flow time 5.13–5.47 s; angle of repose 21.54–22.56○; Tap-Bulk 0.070–0.078 gmL−1 ; tablet weight 699.7–702.0 mg; tablet hardness 7.9–8.4 kp; Tablet friability 0.70–0.86% and tablet disintegration time 0.52–1.63 min. The optimum concentration(2%) improves the flow time and angle of repose of the mixture mass. Increasing the concentration of P-2HTCb causes the Tap-Bulk value of the mixture mass and tablet friability to decrease, but increases tablet hardness. The optimum concentration (1 %) provides the fastest disintegration time. P-2HTCb produces minimal dust when mixed with LG material. P-2HTCb can be recommended as an alternative glidant candidate in environmentally and health-friendly pharmaceutical formulations
| Item Type: | Article |
|---|---|
| Subjects: | Pharmacy |
| Divisions: | Journal Publication |
| Depositing User: | Jefri Prasetyo |
| Date Deposited: | 13 Aug 2026 05:58 |
| Last Modified: | 13 Aug 2026 05:58 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/47690 |
Actions (login required)
 |
View Item |