Sincihu, Yudhiakuari, Jong, FX. Himawan Haryanto, Julian, Alvin, Herjunianto, Herjunianto, Herdiani, Novera, Mulyasari, Tri Marthy, Setyobudi, Roy Hendroko, Hermayanti, Diah, Lestari, Kusuma Scorpia and Ningrum, Prehatin Trirahayu (2026) The Garcinia Mangostana L. Peel Extract Reduces Fecal Microbiota Count and Malondialdehyde Expression of Intestinal Epithelium in Microplastic-Induced Rats. Journal of Widya Medika Junior, 8 (1). pp. 10-20. ISSN 26561409
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Text (The Garcinia Mangostana L. Peel Extract Reduces Fecal Microbiota Count and Malondialdehyde Expression of Intestinal Epithelium in Microplastic-Induced Rats)
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Abstract
Background: Microplastics (MP) are emerging food contaminants that can penetrate the bloodstream and induce oxidative stress and inflammation. Intestinal microbiome dysbiosis and damage to the intestinal epithelial phospholipid membrane are considered key biomarkers of MP-induced toxicity in the gastrointestinal tract. Objective: This study aimed to evaluate the potential of Garcinia mangostana L. peel extract (MPE) to maintain gut microbiome homeostasis and protect the intestinal epithelium of Wistar rats exposed to low-density polyethylene (LDPE) microplastics. Methods: This was a true experimental study involving 35 Wistar rats randomly assigned to five groups: negative control (KN), positive control (KP), and three treatment groups (K1, K2, and K3). LDPE MPs were administered orally at a dose of 5 mg/day to the KP, K1, K2, and K3 groups. MPE was administered orally to the treatment groups at doses of 200 mg/kgBW/day (K1), 400 mg/kgBW/day (K2), and 600 mg/kgBW/day (K3). Results: One-way ANOVA demonstrated that MPE significantly reduced intestinal microbiome dysbiosis (p = 0.001; 95% CI), as indicated by mean total plate count values (CFU/mL × 10⁶): KN = 8.37 ± 0.90; KP = 11.70 ± 0.99; K1 = 11.46 ± 0.84; K2 = 8.65 ± 1.20; and K3 = 9.39 ± 0.47. MPE also significantly attenuated intestinal epithelial membrane damage (p = 0.001; 95% CI), as shown by mean malondialdehyde expression levels (% immunoreactive area): KN = 11.84 ± 0.91; KP = 25.84 ± 3.24; K1 = 21.08 ± 6.59; K2 = 18.65 ± 3.22; and K3 = 14.09 ± 1.71. Conclusion: These findings suggest that Garcinia mangostana L. peel extract has protective potential in preserving gut microbiome homeostasis and preventing intestinal epithelial damage induced by microplastic exposure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Dysbiosis; Garcinia mangostana L; Intestinal epithelium; Malondialdehyde; Microplastics. |
| Subjects: | Medicine |
| Divisions: | Journal Publication |
| Depositing User: | F.X. Hadi |
| Date Deposited: | 07 Apr 2026 02:48 |
| Last Modified: | 07 Apr 2026 02:48 |
| URI: | https://repositori.ukwms.ac.id/id/eprint/46540 |
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